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Practice points for varenicline use There is insufficient evidence to recommend combining varenicline with any other smoking cessation medication Varenicline is contraindicated in young people aged under 18 years and in women who are pregnant or breastfeeding Dose adjustment is not required for older people or people with mild to moderate renal or hepatic impairment

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Results Cellular diversity in the human tracheal epithelium To interrogate cellular diversity within the human tracheal epithelium, we enzymatically dissociated tracheal specimens from fifteen donors and then subjected these cells to scRNA-seq (Fig